Knowledge About Clinical Research,Immunology and Cell Biology of Clinical Research

Immunology and Cell Biology of clinical research

Immunology and Cell Biology is an academic journal of the Australian and New Zealand Society of Immunology covering basic immunology research. The journal has a focus on cellular immunology, innate and adaptive immunity, immune responses to pathogens, tumour immunology, immunopathology, immunotherapy, immunogenetics and immunological studies in humans and model organisms (including mouse, rat, Drosophila etc.). The journal was founded in 1924 as the Australian Journal of Experimental Biology and Medical Science, and was converted in 1987 to Immunology and Cell Biology, making it one of the oldest speciality immunology journals in existence. Major historical contributions including publication by Donald Metcalf of the strategy for identifying colony-stimulating factors (CSFs) and the development of the clonal selection theory by Frank Macfarlane Burnet, in a series of more than 90 publications in the 1970s.

The journal's editor-in-chief is Anne La Flamme, with Adrian Liston, Sammy Bedoui and Ian Parish serving as deputy editors. ICB has a sister journal, Clinical and Translational Immunology, which was founded in 2012 in response to a growing need for publishing clinically-orientated research papers in the field of immunology.

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Society for Hematology and Stem Cells of clinical research

The Society for Hematology and Stem Cells (formerly the International Society for Experimental Hematology) is a learned society which deals with hematology, the study of the blood system and its diseases, including those caused by exposure to nuclear radiation. It was founded in 1950, and held its first official meeting in Milwaukee in 1972. Its mission statement is: "To promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy and related aspects of research through publications, discussions, scientific meetings and the support of young investigators."

Dr. Margaret Goodell of the Baylor College of Medicine's Center for Cell and Gene Therapy is the current president.

At the opening ceremony of the 30th annual meeting of ISEH, Emperor Akihito of Japan praised the "remarkable results obtained by the ISEH today in the treatment of radiation-related disorders", by contrast to the lack of any effective treatment for such disorders in 1945 when atomic bombs were dropped on Hiroshima and Nagasaki.

The society has an official journal, Experimental Hematology, which has an impact factor of 2.907.

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Robin Carrell of clinical research

Robin Wayne Carrell (born 5 April 1936) is a New Zealand-born haematologist.

Born in 1936, Carrell was educated at Christchurch Boys' High School from 1949 to 1953. He graduated MB ChB from the University of Otago in 1959, and BSc(Hons) in chemistry and biochemistry from the University of Canterbury and Lincoln College in 1965. He completed his PhD at the University of Cambridge in 1967 and in 1968 he was appointed head of clinical biochemistry at Christchurch Hospital, the department later becoming part of the University of Otago Christchurch School of Medicine. As a spin-off from his research he co-founded biotechnology company Canterbury Scientific in 1985. He returned to Cambridge the following year as professor of haematology, retiring in 2003, but as professor emeritus he has continued his research at Cambridge. He retired from the board of directors of Canterbury Scientific in 2012.

In 1986 he won the Hector Medal, at the time the highest award in New Zealand science. He was elected a Fellow of the Royal Society of New Zealand in 1980, a Fellow of Trinity College, Cambridge in 1987, and a Fellow of the Royal Society in 2002.

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Mike Grocott of clinical research

Mike Grocott MBBS MD FRCA FRCP FFICM is professor of anaesthesia and critical care medicine at the University of Southampton and director designate of the Southampton NIHR Biomedical Research Centre. He is an NIHR Senior Investigator (2018-22 and national specialty group lead for Anaesthesia Perioperative Medicine and Pain within the NIHR Clinical Research Network (2015-2022). He is a consultant in critical care medicine at University Hospital Southampton NHS Foundation Trust.

Grocott is an elected council member and vice-president of the Royal College of Anaesthetists.

He has served as the chair of the board of the National Institute of Academic Anaesthesia (NIAA) since 2018 and was previously the founding director of the NIAA Health Services Research Centre at the Royal College of Anaesthetists (2011-2016) and founding chair of the HQIP funded National Emergency Laparotomy Audit (2012-2017).

In 2007 Grocott summited Everest as leader of the Caudwell Xtreme Everest medical research expedition and is the founding chair of the Xtreme Everest Oxygen Research Consortium.

He lives in the New Forest with his wife, Professor Denny Levett, three children and two degus.

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Committee Memberships of clinical research

Hungarian Society of Gastroenterology

Hungarian Society of Pancreatology

Hungarian Society of Endoscopy

Hungarian Endosonography Club

International Association of Pancreatology

European Pancreatic Club

American Pancreatic Association

European Group of Endoscopic Utrasonography

European Society of Digestive Oncology

European Society of Gastrointestinal Endoscopy

Hungarian Society of Internal Medicine

Hungarian Society of Diabetes

Hungarian Society of Hypertension

Hungarian Society of Clinical Nutrition

Public Corporation of the Hungarian Academy of SciencesEditorial Board MembershipsJournal of Gastroenterology (2010-2012)

Word Journal of Gastroenterology (2009-2011)

World Journal of Gastrointestinal Pharmacology and Therapeutics (2010-2019)

Frontiers in Gastrointestinal Sciences (2010-215)

World Journal of Gastrointestinal Pathophysiology (2011-2019)

Gastroenterology and Hepatology (2011-2015)

Journal of Gastroenterology and Hepatology Research (2011-2014) (Associate Editors-In-Chief)

International Scholarly Research Network Inflammation (2011-2014)

Journal of Hypo & Hyperglycemia (2012-)

Global Journal of Gastroenterology & Hepatology (2013-)

World Journal of Methodology (2013-)

Gastroenterological and Intestinal System (2013-)

World Journal of Gastrointestinal Endoscopy (2013-)

Journal of Gastroenterology, Pancreatology & Liver Disorders (2013-)

World Journal of Methodology (2014- )

Pancreas Open Journal (Associate Editor 2015 - )

International J. of Gastroenterology Disorders & Therapy (2015 - )

Iore Journal of Gastroenterology (2015 -)

Gastroenterology & Hepatology International Journal (2017- )

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Development of clinical research

Integrative behavioral couple therapy (IBCT) was developed by Neil S. Jacobson and Andrew Christensen. The model represents a return to contextualism, functional analysis and Skinner's distinction between contingency shaped and rule governed behavior. Integrative Behavioral Couple Therapy is "integrative" in at least two senses: First, it integrates the twin goals of acceptance and change as positive outcomes for couples in therapy. Couples who succeed in therapy usually make some concrete changes to accommodate the needs of the other but they also show greater emotional acceptance of the other. Second, IBCT integrates a variety of treatment strategies under a consistent behavioral theoretical framework. It is considered a third generation behavior therapy or sometimes called clinical behavior analysis.

Both the integrative and traditional behavioral couples therapy models have origins primarily in behaviorism. While traditional behavioral couples therapy has more roots in social learning principles and the later model in Skinnerian behaviorism. The latter model draws heavily on the use of functional analysis (psychology) and the Skinnerian distinction between contingency shaped and rule governed behavior to balance acceptance and change in the relationship.

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Tarlochan Singh Kler of clinical research

Tarlochan Singh Kler is an Indian interventional cardiologist, medical administrator, writer, Chairman at Pushpawati Singhania Hospital & Research Institute and (former Director of Cardiac Sciences at Fortis Escorts Heart Institute). Born in Amargarh in the Indian state of Punjab, he graduated in medicine from Punjabi University in 1976, secured his MD in general medicine from Postgraduate Institute of Medical Education and Research (PGIMER) in 1980 and followed it up with the degree of DM in cardiology from the same institution in 1983. He succeeded Naresh Trehan as the executive director of Fortis Heart Institute and Research Centre before becoming its director. He has written several articles on interventional cardiology; Persistent left superior vena cava opening directly into right atrium and mistaken for coronary sinus during biventricular pacemaker implantation, Mammary coronary artery anastomosis without cardiopulmonary bypass through minithoracotomy: one year clinical experience, and Ventricular Fibrillation in the EP Lab. What is the Atrial Rhythm? are some of the notable ones. The Government of India awarded him the third highest civilian honour of the Padma Bhushan, in 2005, for his contributions to medicine.

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Centre for Statistics in Medicine of clinical research

The Centre for Statistics in Medicine (CSM) at the University of Oxford, United Kingdom was founded by Professor Douglas G. Altman until 2018. He was succeeded by Professor Sallie Lamb until 2019. In 1995 it was based at the Institute of Health Sciences in Headington, Oxford, it relocated to the annexe of Wolfson College, Oxford in 2005, and in 2013 moved to the Botnar Research Centre in Headington.

The CSM incorporates the Cancer Research UK Medical Statistics Group (MSG), Oxford Clinical Trial Research Unit statisticians and the UK EQUATOR Centre. It is based in the Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences in the University of Oxford.

CSM collaborates in health care research, conducts applied statistical research and runs training courses/workshops for both health care workers and statisticians.

Statisticians within the CSM are involved in many collaborative projects with clinicians in Oxford and further afield, some working across the medical spectrum and others focusing on cancer. Other statisticians within the CSM work primarily on a programme of methodological research, in particular relating to studies of diagnosis and prognosis, and to systematic reviews and meta-analysis.

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Similar Roles in the United States of clinical research

Although the label of "Clinical Associate" or "Clinical Associate in Applied Psychology (CAAP)" is unique to Scotland, there are other countries that also allow holders of master's degrees in Clinical Psychology to practice in somewhat limited capacities.

In the United States, there are a number of U.S. schools that offer master's degree programs in Clinical Psychology. These programs often take 2 to 3 years to complete post-Bachelor's degree and the training usually emphasizes theory and treatment over research, quite often with a focus on school or couples and family counseling. While many graduates of master's-level training programs go on to earn their Doctorate in Clinical Psychology, a large number chose to go directly into practiceoften as a Marriage and Family Therapist (MFT), Licensed Psychological Associate (LPA), or Licensed Professional Counselor (LPC). When working under the supervision of a doctoral psychologist, masters graduates can work as Psychological Assistants in clinical, counseling, or research settings.

Most master's degree programs do not require an undergraduate major in psychology, but do require coursework in introductory psychology, experimental psychology, and statistics.

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Khawla Al Khuraya of clinical research

Khawla S. Al-Kuraya is a Saudi physician and cancer specialist. She is a professor of pathology and directs the King Fahad National Center for Children's Cancer and Research.

Al-Kuraya was born in the Al Jawf Region of Saudi Arabia. She was admitted to King Saud University in Riyadh and earned her MD in general surgery and medicine. She completed her residency in clinical pathology in Washington D.C. at Georgetown University Hospital. She then completed a fellowship in molecular diagnostics and hematopathology at the National Cancer Institute.

Al-Kuraya first identified the FOSM1 gene, which prompts the human body to form cancer cells.

For her cancer research Al-Kuraya was awarded the Order of Abdulaziz al Saud in 2010. She was the first Saudi woman to receive the award. Saudi newspapers and television depicted King Abdullah shaking her hand and placing the medal around her neck. The public display of proximity to an unrelated woman was unprecedented at the time.

She was among 30 women who in 2013 were appointed by King Abdullah to the Consultative Assembly of Saudi Arabia, an advisory body that proposes laws.

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Clinical significance of clinical research

Variants in the PALB2 gene are associated with an increased risk of developing breast cancer of magnitude similar to that associated with BRCA2 mutations and PALB2-deficient cells are sensitive to PARP inhibitors.

PALB2 was recently identified as a susceptibility gene for familial pancreatic cancer by scientists at the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins. This has paved for the way for developing a new gene test for families where pancreatic cancer occurs in multiple family members. Tests for PALB2 have been developed by Ambry Genetics and Myriad Genetics that are now available. The PALB2 Interest Group (PALB2.org) is an international consortium of scientists and clinicians who coordinate research into this gene. They are keen to hear from women and men with PALB2 mutations.

Prophylactic mastectomy should be considered for women that had breast cancer and a PALB2 mutation.

Biallelic mutations in PALB2 (also known as FANCN), similar to biallelic BRCA2 mutations, cause Fanconi anemia.

Mutations in this gene have been associated with an increased risk of ovarian, breast and pancreatic cancer.

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